Investigating how age and gender affect brain inflammation and cognitive issues after surgery in older adults
Targeting age and gender-dependent microglia-mediated mechanisms underlying postoperative cognitive impairment for treatment of delirium in the elderly
This study is looking at how certain brain cells might cause confusion after surgery in older adults, especially focusing on how inflammation affects this, and it hopes to find ways to prevent or treat these issues for seniors.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10763044 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of microglia, the brain's immune cells, in causing cognitive problems like delirium after surgery in older adults. It examines how inflammation in the body and brain can lead to these cognitive issues, particularly looking at differences based on age and gender. By studying mouse models, the research aims to identify specific molecular mechanisms that contribute to delirium, which could lead to better prevention and treatment strategies for elderly patients undergoing surgery.
Who could benefit from this research
Good fit: Ideal candidates for this research are elderly individuals who are scheduled to undergo major surgery.
Not a fit: Patients who are not elderly or those who are not undergoing surgery may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved methods for preventing and treating delirium in older adults after surgery.
How similar studies have performed: Previous research has shown promising results in understanding the role of microglia in cognitive dysfunction, suggesting that this approach could lead to significant advancements in treatment.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Kamiya, Atsushi — Johns Hopkins University
- Study coordinator: Kamiya, Atsushi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.