Investigating how age affects vision through lipid metabolism
Role of ELOVL2 in age-related visual decline
This study is looking at how changes in fats in the body might affect eye health as we get older, especially for those with age-related macular degeneration (AMD), and it invites older adults to help by sharing samples or information about their vision.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project ID | NIH-11015774 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of lipid metabolism in age-related macular degeneration (AMD), a leading cause of vision loss in older adults. The study examines how changes in the retinal pigment epithelium (RPE), which is crucial for maintaining healthy vision, are influenced by age-related alterations in lipid levels. By analyzing the impact of specific fatty acids on RPE function, the research aims to uncover mechanisms that contribute to visual decline as people age. Patients may be involved in providing biological samples or participating in assessments related to their vision and age.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing early signs of age-related macular degeneration.
Not a fit: Patients with other forms of vision impairment unrelated to age or AMD may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating age-related vision loss.
How similar studies have performed: Previous research has shown promising results in understanding lipid metabolism's role in eye health, suggesting potential for breakthroughs in AMD treatment.
Where this research is happening
Irvine, United States
- University of California-Irvine — Irvine, United States (Active)
Researchers
- Principal investigator: Tom, Emily — University of California-Irvine
- Study coordinator: Tom, Emily
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.