Investigating how age affects the immune response related to type 2 diabetes
Age-related impairment in anti-HMGB1 IgM response potentiates type 2 diabetes
['FUNDING_R21'] · UNIVERSITY OF ILLINOIS AT CHICAGO · NIH-10665749
This study is looking at how aging affects a specific antibody that helps control inflammation related to type 2 diabetes, to better understand why older adults might be at a higher risk for the condition.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF ILLINOIS AT CHICAGO (nih funded) |
| Locations | 1 site (Chicago, UNITED STATES) |
| Trial ID | NIH-10665749 on ClinicalTrials.gov |
What this research studies
This research explores the connection between age-related immune response and type 2 diabetes (T2D). It focuses on a specific antibody, anti-HMGB1 IgM, which helps regulate inflammation linked to T2D. By studying how this antibody's response diminishes with age, the research aims to understand its role in increasing diabetes risk among older adults. The methodology includes analyzing immune responses in both animal models and human blood samples to identify potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults, particularly females, who are at risk for type 2 diabetes or have early signs of insulin resistance.
Not a fit: Patients who are younger and do not have risk factors for type 2 diabetes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating type 2 diabetes in older adults.
How similar studies have performed: Previous research has shown promising results in understanding the immune response related to diabetes, suggesting that this approach could yield valuable insights.
Where this research is happening
Chicago, UNITED STATES
- UNIVERSITY OF ILLINOIS AT CHICAGO — Chicago, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHEN, AOSHUANG — UNIVERSITY OF ILLINOIS AT CHICAGO
- Study coordinator: CHEN, AOSHUANG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.