Investigating how age affects the effectiveness of enoxaparin in preventing blood clots in critically ill children
Official title: Age-dependent heterogeneity in the efficacy of prophylaxis with enoxaparin against catheter-associated thrombosis in critically ill children
Funded at Yale University · NIH-10893387 · Data updated 2026-11-12
This study is looking at how well enoxaparin, a blood thinner, works for critically ill kids of different ages who are at risk for blood clots, to find the best ways to keep them safe and healthy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | September 10, 2021 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $689,349 |
| NIH project number | 5R01HD106326-04 |
| Project ID | NIH-10893387 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are critically ill children, particularly those under 21 years old, who require central venous catheters.
✕Less likely to help
Patients who are not critically ill or do not require central venous catheters may not benefit from this research.
What this research studies
This research focuses on understanding how the effectiveness of enoxaparin, a common anticoagulant, varies with age in critically ill children at risk for catheter-associated blood clots. The study will involve administering enoxaparin to children and comparing the outcomes to those receiving standard care. By analyzing data from previous clinical trials, the researchers aim to identify the most effective age groups for this treatment. This could lead to tailored prophylactic strategies that better protect young patients from serious complications.
Why it matters
Potential benefit: If successful, this research could significantly reduce the incidence of catheter-associated blood clots in critically ill children, improving their overall health outcomes.
How similar studies have gone: Previous studies have shown promising results with similar approaches in adult populations, but this specific age-dependent analysis in children is novel.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Faustino, Edward Vincent — Yale University
- Study coordinator: Faustino, Edward Vincent
Related research
Other NIH-funded projects on the same topics.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.