Investigating how age affects T cell signaling and immune response
Proteome-wide base editor screens to assess phosphorylation site functionality in immunosenescence
['FUNDING_R01'] · LA JOLLA INSTITUTE FOR IMMUNOLOGY · NIH-11072080
This study is looking at how changes in T cells, which are important for our immune system, affect their ability to fight off illnesses as we get older, and it aims to find ways to boost their strength in older adults.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | LA JOLLA INSTITUTE FOR IMMUNOLOGY (nih funded) |
| Locations | 1 site (LA JOLLA, UNITED STATES) |
| Trial ID | NIH-11072080 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the complex signaling pathways in T cells, particularly how phosphorylation events influence their function as we age. By using advanced techniques like CRISPR-mediated base editing and mass spectrometry, the study aims to identify and assess thousands of phosphorylation sites that play a crucial role in T cell activity. This could help uncover why older adults experience weakened immune responses, particularly against cancer and infections. The goal is to develop new strategies to enhance T cell function in aging populations.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing weakened immune responses or those interested in adoptive cell therapies.
Not a fit: Patients who are younger and do not have issues related to immune senescence may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved immune therapies for older adults, enhancing their ability to fight infections and cancer.
How similar studies have performed: Previous research has successfully utilized CRISPR and mass spectrometry to analyze cellular processes, indicating a promising approach for this study.
Where this research is happening
LA JOLLA, UNITED STATES
- LA JOLLA INSTITUTE FOR IMMUNOLOGY — LA JOLLA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MYERS, SAM ANTHONY — LA JOLLA INSTITUTE FOR IMMUNOLOGY
- Study coordinator: MYERS, SAM ANTHONY
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.