Investigating how age affects mitochondrial function in brain cells after spinal cord injury
Understanding the age-dependent mitochondrial function in astrocytes after spinal cord injury via bi-directional manipulation of activity
This study is looking at how spinal cord injuries affect certain brain cells as people get older, and it aims to find ways to improve recovery for older patients by boosting the energy production in those cells.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Texas A&m University Health Science Ctr NIH-funded |
| Lab location | 1 site (College Station, United States) |
| Project ID | NIH-10897178 on NIH RePORTER |
What this research studies
This research focuses on understanding how spinal cord injuries (SCI) impact mitochondrial function in astrocytes, a type of brain cell, particularly as patients age. The study aims to explore the differences in recovery based on age, as older individuals often experience a decline in mitochondrial function that can hinder recovery. By manipulating mitochondrial activity in a targeted manner, the researchers hope to identify strategies that could enhance recovery outcomes for patients with SCI. The approach includes both in vitro experiments and potential applications for improving treatment protocols for aging populations.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults who have experienced a spinal cord injury.
Not a fit: Patients who are younger and have not sustained a spinal cord injury may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved recovery strategies for older patients suffering from spinal cord injuries.
How similar studies have performed: Previous research has indicated that targeting mitochondrial function can yield positive outcomes in similar contexts, suggesting a promising avenue for this investigation.
Where this research is happening
College Station, United States
- Texas A&m University Health Science Ctr — College Station, United States (Active)
Researchers
- Principal investigator: Geoffroy, Cedric G — Texas A&m University Health Science Ctr
- Study coordinator: Geoffroy, Cedric G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.