Investigating how age affects chromosome separation in sperm
How age-dependent alterations in meiotic recombination cause chromosome mis-segregation in sperm
This study is looking into how aging affects the way chromosomes are sorted during sperm production, which can lead to problems like infertility and miscarriages, and it aims to find ways to improve reproductive health for those facing these challenges.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tx Md Anderson Can Ctr NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10842588 on NIH RePORTER |
What this research studies
This research explores the mechanisms behind chromosome mis-segregation during sperm formation, particularly how age-related changes in meiotic recombination contribute to this issue. By studying mouse models and human spermatocytes, the researchers aim to understand the balance between crossover and noncrossover events during meiosis. The goal is to identify the molecular factors that lead to errors in chromosome segregation, which can result in infertility, miscarriages, and birth defects. The findings could pave the way for new therapies to improve reproductive health.
Who could benefit from this research
Good fit: Ideal candidates for this research are adult males experiencing infertility or those with a history of miscarriages or congenital abnormalities in offspring.
Not a fit: Patients who are not male or those without reproductive health concerns may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing infertility and reducing the risk of birth defects.
How similar studies have performed: Previous research has shown that understanding meiotic processes can lead to significant advancements in reproductive health, indicating that this approach has potential for success.
Where this research is happening
Houston, United States
- University of Tx Md Anderson Can Ctr — Houston, United States (Active)
Researchers
- Principal investigator: Cole, Francesca — University of Tx Md Anderson Can Ctr
- Study coordinator: Cole, Francesca
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.