Investigating how African ancestry affects immune responses in breast cancer disparities
The DARC side of Breast Cancer Disparities - African Ancestry and Cancer- Related Immune Response
['FUNDING_R01'] · MOREHOUSE SCHOOL OF MEDICINE · NIH-10689862
This study is looking into why triple-negative breast cancer is more common in African American women and how their unique genetics might affect their immune system's response to the cancer, with the goal of finding out more about the reasons behind these differences.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MOREHOUSE SCHOOL OF MEDICINE (nih funded) |
| Locations | 1 site (ATLANTA, UNITED STATES) |
| Trial ID | NIH-10689862 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the reasons behind the higher rates of triple-negative breast cancer (TNBC) in African American women. It explores how unique genetic variants linked to African ancestry may influence immune responses to tumors, potentially leading to worse outcomes. By analyzing gene expression and immune cell behavior in TNBC patients, the study aims to uncover the biological mechanisms that contribute to these disparities. The research involves a multiomics approach, examining various biological data to provide a comprehensive view of the tumor-immune interactions in this population.
Who could benefit from this research
Good fit: Ideal candidates for this research are African American women diagnosed with triple-negative breast cancer.
Not a fit: Patients who do not have triple-negative breast cancer or those outside the African American demographic may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment strategies for breast cancer in African American women.
How similar studies have performed: While there has been some research on breast cancer disparities, this study's focus on African-specific genetic variants and immune responses is relatively novel.
Where this research is happening
ATLANTA, UNITED STATES
- MOREHOUSE SCHOOL OF MEDICINE — ATLANTA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DAVIS, MELISSA B — MOREHOUSE SCHOOL OF MEDICINE
- Study coordinator: DAVIS, MELISSA B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.