Investigating how AEBP1 contributes to heart tissue scarring after injury
Official title: Understanding the mechanism of AEBP1-mediated fibrosis post-cardiac injury in heart failure
Funded at VA Salt Lake City Healthcare System · NIH-11003655 · Data updated 2026-11-12
This study is looking at a protein called AEBP1 to see how it affects heart healing after injury, with the hope of finding new treatments to help people recover better from heart problems.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | VA Salt Lake City Healthcare System NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project start | January 1, 2024 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| NIH project number | 5I01BX006306-02 |
| Project ID | NIH-11003655 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with heart failure who are scheduled for heart surgeries such as left ventricular assist device implantation or heart transplantation.
✕Less likely to help
Patients with heart conditions unrelated to fibrosis or those not undergoing surgical interventions may not benefit from this research.
What this research studies
This research focuses on understanding the role of a protein called AEBP1 in the development of cardiac fibrosis, which is a common complication following heart injury. By studying heart tissue from patients undergoing heart surgeries, the researchers aim to uncover how AEBP1 affects the healing process and contributes to heart failure. The approach involves analyzing tissue samples and using advanced techniques to explore the molecular mechanisms behind AEBP1's role in fibrosis. The ultimate goal is to identify potential therapies that could inhibit AEBP1 and improve heart recovery.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that reduce heart tissue scarring and improve recovery for patients with heart failure.
How similar studies have gone: Previous research has shown promising results in targeting similar pathways for fibrosis treatment, indicating potential for success in this approach.
Where this research is happening
-
VA Salt Lake City Healthcare System
Salt Lake City, United States Active
Researchers
- Principal investigator: Drakos, Stavros George — VA Salt Lake City Healthcare System
- Study coordinator: Drakos, Stavros George
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.