Investigating how adrenomedullin 2 affects intestinal inflammation
Official title: Adrenomedullin 2 Regulates ILC2 Responses to Control Intestinal Inflammation
Funded at Weill Medical Coll of Cornell Univ · NIH-11070733 · Data updated 2026-11-12
This study is looking at how a substance called adrenomedullin 2 (ADM2) affects the immune system and inflammation in the intestines, especially for people with inflammatory bowel disease (IBD), to find new ways to help improve treatments for those affected.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | January 1, 2025 |
| Project end | December 31, 2025 |
| Funding year | 2025 |
| Award (this year) | $77,140 |
| NIH project number | 1F32DK139586-01A1 |
| Project ID | NIH-11070733 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with inflammatory bowel diseases such as ulcerative colitis or Crohn's disease.
✕Less likely to help
Patients with non-inflammatory bowel conditions or those not diagnosed with IBD may not benefit from this research.
What this research studies
This research focuses on understanding the role of adrenomedullin 2 (ADM2) in regulating immune responses related to intestinal inflammation, particularly in conditions like inflammatory bowel disease (IBD). The study aims to explore how ADM2 interacts with specific receptors to influence inflammation and tissue repair in the intestines. By examining both human and mouse models, researchers hope to uncover new therapeutic targets that could lead to better treatment options for patients suffering from IBD.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that more effectively manage or even prevent inflammatory bowel diseases.
How similar studies have gone: Previous studies have shown promise in targeting neuropeptides for treating intestinal inflammation, suggesting that this approach could yield significant insights.
Where this research is happening
-
Weill Medical Coll of Cornell Univ
New York, United States Active
Researchers
- Principal investigator: Uddin, Jazib Naseer — Weill Medical Coll of Cornell Univ
- Study coordinator: Uddin, Jazib Naseer
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.