Investigating how ADNP affects RNA structures during cell development
ADNP mechanisms in R-loop regulation during differentiation
['FUNDING_R01'] · WISTAR INSTITUTE · NIH-10887500
This study is looking at how a protein called ADNP helps control certain RNA structures that are important for cell development, which could help us understand more about developmental disorders and cancers.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WISTAR INSTITUTE (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-10887500 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of the Activity dependent neuroprotective protein (ADNP) in regulating RNA structures known as R-loops, which are important for proper cell differentiation. By studying how ADNP interacts with these structures, the research aims to uncover mechanisms that may contribute to developmental disorders and cancers. The approach includes biochemical assays and experiments using mouse embryonic stem cells to observe the effects of ADNP on R-loop regulation. This could provide insights into how disruptions in these processes lead to various diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with ADNP syndrome or related developmental disorders.
Not a fit: Patients without genetic mutations affecting ADNP or those with unrelated developmental disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for conditions associated with ADNP mutations, such as intellectual disabilities and autism spectrum disorder.
How similar studies have performed: While the specific role of ADNP in R-loop regulation is novel, similar studies have shown that understanding chromatin structure can lead to breakthroughs in treating developmental disorders and cancers.
Where this research is happening
PHILADELPHIA, UNITED STATES
- WISTAR INSTITUTE — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SARMA, KAVITHA — WISTAR INSTITUTE
- Study coordinator: SARMA, KAVITHA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers, Disease, Disorder