Investigating how adenosine changes to inosine in single neurons
Profiling of adenosine to inosine editing in single neurons
This study is looking at how a change in a brain chemical affects nerve cells and could help us understand conditions like ALS and other neurological disorders, so we can learn more about how these changes impact brain health.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project ID | NIH-11230443 on NIH RePORTER |
What this research studies
This research focuses on a specific chemical modification in the nervous system where adenosine is converted to inosine, a process that can alter the proteins produced by neurons. By using advanced sequencing techniques, the study aims to identify how this modification varies among different types of neurons and its implications for brain development and diseases. Patients may benefit from understanding how these changes affect conditions like amyotrophic lateral sclerosis and other neurological disorders. The research will involve analyzing neuronal mRNA to determine the efficiency of this editing process in various neuronal contexts.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with amyotrophic lateral sclerosis or other neurological disorders linked to adenosine to inosine editing.
Not a fit: Patients with conditions unrelated to neurological disorders or those not experiencing symptoms related to adenosine editing may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the mechanisms of neurological diseases and potential therapeutic targets.
How similar studies have performed: Previous research has shown promising results in understanding the role of RNA editing in various neurological conditions, suggesting that this approach could yield valuable insights.
Where this research is happening
Portland, United States
- Oregon Health & Science University — Portland, United States (Active)
Researchers
- Principal investigator: Nechiporuk, Alex — Oregon Health & Science University
- Study coordinator: Nechiporuk, Alex
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.