Investigating how adenosine changes to inosine in single neurons
Official title: Profiling of adenosine to inosine editing in single neurons
Funded at Oregon Health & Science University · NIH-11230443 · Data updated 2026-11-12
This study is looking at how a change in a brain chemical affects nerve cells and could help us understand conditions like ALS and other neurological disorders, so we can learn more about how these changes impact brain health.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project start | June 1, 2025 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $420,744 |
| NIH project number | 1R21NS140812-01A1 |
| Project ID | NIH-11230443 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with amyotrophic lateral sclerosis or other neurological disorders linked to adenosine to inosine editing.
✕Less likely to help
Patients with conditions unrelated to neurological disorders or those not experiencing symptoms related to adenosine editing may not benefit from this research.
What this research studies
This research focuses on a specific chemical modification in the nervous system where adenosine is converted to inosine, a process that can alter the proteins produced by neurons. By using advanced sequencing techniques, the study aims to identify how this modification varies among different types of neurons and its implications for brain development and diseases. Patients may benefit from understanding how these changes affect conditions like amyotrophic lateral sclerosis and other neurological disorders. The research will involve analyzing neuronal mRNA to determine the efficiency of this editing process in various neuronal contexts.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the mechanisms of neurological diseases and potential therapeutic targets.
How similar studies have gone: Previous research has shown promising results in understanding the role of RNA editing in various neurological conditions, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Oregon Health & Science University
Portland, United States Active
Researchers
- Principal investigator: Nechiporuk, Alex — Oregon Health & Science University
- Study coordinator: Nechiporuk, Alex
Related research
Other NIH-funded projects on the same topics.
-
Understanding how a protein affects nerve cell movement in Alzheimer's disease
This study is looking at how a protein called APP affects the growth and movement of nerve cells, which is important for understanding Alzheimer's disease, and it aims to find out how problems with this protein might lead to nerve cell damage.
-
Understanding how the bone marrow environment drives AML resistance
A large NIH-funded project at Oregon Health & Science University is studying how the body’s own cell surroundings help acute myeloid leukemia become resistant to treatment, with potential paths to better therapies for patients.
-
Improving Safety at Work with a Low-Resource mHealth Program in Malaysia (and beyond)
A low-cost mobile health program to improve safety culture in Malaysian workplaces, with plans to adapt the approach for U.S. workers in high-risk industries.
-
Oregon Healthy Workplace Initiative for Better Health
A multi-site effort aims to improve the health and safety of workers by coordinating research, tools, and interventions across workplaces.
-
Understanding how AML cells become resistant to therapy over time
This project looks at why acute myeloid leukemia stops responding to treatment and how to design better drug combinations to prevent relapse.
-
Mechanisms and Countermeasures for Ultra-Potent Synthetic Opioid Overdose
A small, focused NIH grant aims to understand why ultra-potent synthetic opioids cause severe overdose and to explore potential countermeasures to keep people safe.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.