Investigating how adenine metabolism affects heart repair after injury
Official title: Adenine metabolism in cardiac repair
Funded at University of California Los Angeles · NIH-11144386 · Data updated 2026-11-12
This study is looking at how the body heals after a heart attack, specifically how a substance called adenine affects the repair process, with the goal of finding better ways to help patients recover and strengthen their heart muscle instead of just forming scar tissue.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | July 25, 2024 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $727,945 |
| NIH project number | 5R01HL171307-02 |
| Project ID | NIH-11144386 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced a myocardial infarction or have heart failure.
✕Less likely to help
Patients with non-cardiac related health issues or those who have not experienced heart injury may not benefit from this research.
What this research studies
This research explores the mechanisms behind heart repair following a heart attack, focusing on how adenine metabolism influences the healing process. The team aims to understand how the body’s response to cardiac injury can shift from forming scar tissue to promoting actual heart muscle repair. By studying the biochemical pathways involved, particularly the role of adenine and its effects on heart cells, the researchers hope to identify new therapeutic targets that could improve recovery outcomes for patients. The approach combines expertise from various fields, including cardiac physiology and metabolomics, to develop a comprehensive understanding of the issue.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance heart repair and reduce the risk of heart failure after a heart attack.
How similar studies have gone: Previous research has shown promise in targeting metabolic pathways for cardiac repair, suggesting that this approach could yield significant advancements.
Where this research is happening
-
University of California Los Angeles
Los Angeles, United States Active
Researchers
- Principal investigator: Deb, Arjun — University of California Los Angeles
- Study coordinator: Deb, Arjun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.