Investigating how activated protein C protects the heart from injury
Official title: Activated Protein C in Acute Injury
Funded at G V Sonny Montgomery VA Medcial Center · NIH-11005694 · Data updated 2026-11-12
This study is looking at how a natural enzyme called activated protein C can help protect the hearts of older veterans from damage during heart attacks, with the goal of finding new ways to treat heart disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | G V Sonny Montgomery VA Medcial Center NIH-funded |
| Lab location | 1 site (Jackson, United States) |
| Project start | November 1, 2022 |
| Project end | October 31, 2026 |
| Funding year | 2025 |
| NIH project number | 5I01CX002406-03 |
| Project ID | NIH-11005694 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include aging veterans with ischemic heart disease or related cardiovascular conditions.
✕Less likely to help
Patients without ischemic heart disease or those who are not veterans may not benefit from this research.
What this research studies
This research focuses on understanding how activated protein C (APC), a natural anticoagulant enzyme, can protect the heart from damage caused by ischemic events, particularly in aging veterans. The study examines the mechanisms by which APC stabilizes its receptor and enhances cardiac tolerance to ischemic insults. By comparing the effects of APC on myocardial infarction in veteran patients versus healthy individuals, the research aims to uncover the cardioprotective signaling pathways activated by APC treatment. This could lead to new therapeutic strategies for managing ischemic heart disease.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for heart conditions, particularly for aging veterans at risk of ischemic heart disease.
How similar studies have gone: Previous research has shown promising results with activated protein C in similar contexts, suggesting potential for success in this investigation.
Where this research is happening
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G V Sonny Montgomery VA Medcial Center
Jackson, United States Active
Researchers
- Principal investigator: Li, Ji — G V Sonny Montgomery VA Medcial Center
- Study coordinator: Li, Ji
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.