Investigating how actin methylation affects gut barrier health and repair
Official title: Actin methylation as a novel mechanism that regulates gut barrier integrity and repair
Funded at Cleveland Clinic Lerner Com-Cwru · NIH-11009559 · Data updated 2026-11-12
This study is looking at how changes to a protein called actin can help keep your gut healthy and repair it when needed, which could lead to new ways to help people with conditions like inflammatory bowel disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | January 15, 2024 |
| Project end | December 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $479,101 |
| NIH project number | 5R01DK137822-02 |
| Project ID | NIH-11009559 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals suffering from inflammatory bowel diseases such as ulcerative colitis or Crohn's disease.
✕Less likely to help
Patients with gastrointestinal disorders unrelated to gut barrier integrity may not benefit from this research.
What this research studies
This research explores the role of actin methylation in maintaining and repairing the gut barrier, which is crucial for gastrointestinal health. It focuses on how modifications to actin proteins can influence the assembly of tight and adherens junctions, as well as the migration of intestinal epithelial cells. By studying these processes, the research aims to uncover new mechanisms that could help in treating conditions like inflammatory bowel disease. Patients with disrupted gut barriers may benefit from insights gained through this investigation.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for improving gut barrier integrity in patients with gastrointestinal disorders.
How similar studies have gone: Preliminary data suggests that similar approaches have shown promise, indicating that this research could build on existing knowledge in the field.
Where this research is happening
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Cleveland Clinic Lerner Com-Cwru
Cleveland, United States Active
Researchers
- Principal investigator: Ivanov, Andrei Ivanovich — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Ivanov, Andrei Ivanovich
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.