Investigating how actin dynamics in neurons affect learning and memory
Official title: Exploring synaptic actin-myosin dynamics with super resolution microscopy
Funded at University of Florida · NIH-10996431 · Data updated 2026-11-12
This study is looking at how a special protein in our brain cells helps with learning and memory by changing the structure of tiny parts called dendritic spines, and it hopes to find out how things like drug use can affect these important processes.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $35,974 |
| NIH project number | 1F31NS139598-01 |
| Project ID | NIH-10996431 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would include individuals with neurological conditions affecting memory and learning.
✕Less likely to help
Patients with conditions unrelated to cognitive function or those not experiencing memory-related issues may not receive any benefit from this research.
What this research studies
This research focuses on understanding the role of Nonmuscle Myosin IIB (NMIIB), a motor protein, in the dynamics of actin filaments within neurons. By using advanced super-resolution microscopy, the study aims to observe how NMIIB influences the structural changes in dendritic spines, which are critical for learning and memory. The research will explore how these processes are affected by stimulation and how they may be disrupted by substances like methamphetamine. Patients may benefit from insights gained about the molecular mechanisms underlying memory and learning.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for enhancing memory and learning in individuals with cognitive impairments.
How similar studies have gone: Previous research has shown that understanding actin dynamics in neurons can significantly impact our knowledge of memory processes, indicating a promising avenue for further exploration.
Where this research is happening
-
University of Florida
Gainesville, United States Active
Researchers
- Principal investigator: Reed, Shayna Jordan — University of Florida
- Study coordinator: Reed, Shayna Jordan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.