Investigating how acetyl-CoA metabolism affects heart cell differentiation
The Role of Acetyl-CoA Metabolism in Epigenetic Regulation of Myofibroblast Differentiation
['FUNDING_FELLOWSHIP'] · TEMPLE UNIV OF THE COMMONWEALTH · NIH-10911837
This study is looking at how the way our cells use a substance called acetyl-CoA affects the healing process in the heart after an injury, with the hope of finding new treatments to prevent heart problems caused by too much scarring.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | TEMPLE UNIV OF THE COMMONWEALTH (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-10911837 on ClinicalTrials.gov |
What this research studies
This research explores the role of acetyl-CoA metabolism in the differentiation of myofibroblasts, which are specialized cells involved in heart repair following injury. By understanding how changes in metabolism influence gene expression through epigenetic modifications, the study aims to identify potential targets for therapies that could prevent excessive fibrosis and heart failure. The approach involves examining metabolic pathways and their effects on histone acetylation, which is crucial for regulating gene activity in these cells. Patients may benefit from insights that could lead to new treatments for heart conditions related to fibrosis.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with heart failure or those at risk of developing heart failure due to cardiac injury.
Not a fit: Patients with heart conditions unrelated to fibrosis or myofibroblast activity may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to novel therapies that prevent or reverse heart failure by targeting myofibroblast differentiation.
How similar studies have performed: Other research has shown promising results in targeting metabolic pathways for therapeutic interventions in heart disease, suggesting this approach has potential.
Where this research is happening
PHILADELPHIA, UNITED STATES
- TEMPLE UNIV OF THE COMMONWEALTH — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LAZAROPOULOS, MICHAEL — TEMPLE UNIV OF THE COMMONWEALTH
- Study coordinator: LAZAROPOULOS, MICHAEL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.