Investigating how ACE inhibitors may extend lifespan and health in fruit flies.
Genetic Basis of Lifespan and Healthspan Extension by ACE Inhibition in Drosophila
This study is looking at how a heart medication called Lisinopril might help improve aging and health by using fruit flies to see how it affects their movement and energy production, which could help us understand why some people respond better to this treatment than others as we age.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Clemson University NIH-funded |
| Lab location | 1 site (Clemson, United States) |
| Project ID | NIH-11105874 on NIH RePORTER |
What this research studies
This research explores the genetic factors that influence how ACE inhibitors, specifically Lisinopril, can improve aging and health in the fruit fly model, Drosophila melanogaster. By studying the effects of these drugs on mobility and mitochondrial function, the researchers aim to uncover the biological mechanisms that could lead to better aging outcomes in humans. The study utilizes a genetic reference panel to analyze variations in response to treatment, which may help identify why some individuals benefit more than others from ACE inhibition. This work could pave the way for personalized approaches to aging and healthspan enhancement.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing age-related health issues or decline.
Not a fit: Patients who are not experiencing age-related conditions or who are younger may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for age-related decline and enhance the quality of life for older adults.
How similar studies have performed: Previous studies have shown promise in using ACE inhibitors for improving age-related conditions, but this specific approach using Drosophila is novel.
Where this research is happening
Clemson, United States
- Clemson University — Clemson, United States (Active)
Researchers
- Principal investigator: Mackay, Trudy F. — Clemson University
- Study coordinator: Mackay, Trudy F.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.