Investigating how abnormal histone acetylation affects Parkinson's disease and related disorders.
Official title: The Role of Aberrant Histone Acetylation in the Pathogenesis of Parkinson’s Disease and Related Synucleinopathies.
Funded at Albert Einstein College of Medicine · NIH-10944689 · Data updated 2026-11-12
This study is looking at how changes in a specific part of our cells might play a role in Parkinson's disease and similar conditions, using special lab-grown brain cells to better understand what happens in these diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albert Einstein College of Medicine NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project start | July 17, 2024 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $682,493 |
| NIH project number | 1R01NS138402-01 |
| Project ID | NIH-10944689 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with Parkinson's disease, Lewy Body Dementia, or Multiple System Atrophy.
✕Less likely to help
Patients with other forms of dementia not related to synucleinopathies may not benefit from this research.
What this research studies
This research explores the role of abnormal histone acetylation in the development of Parkinson's disease and related conditions like Lewy Body Dementia and Multiple System Atrophy. By utilizing a novel human pluripotent stem cell platform, the study aims to replicate disease-relevant characteristics in neuronal cells. The researchers will employ advanced techniques such as SILAC proteomics and genome-wide CRISPR screening to identify factors that modify histone acetylation and contribute to disease pathology. This approach could enhance our understanding of the molecular mechanisms behind these neurodegenerative disorders.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating Parkinson's disease and related dementias.
How similar studies have gone: While the specific approach of using human pluripotent stem cells for this purpose is relatively novel, there is existing evidence that histone acetylation plays a significant role in neurodegenerative diseases.
Where this research is happening
-
Albert Einstein College of Medicine
Bronx, United States Active
Researchers
- Principal investigator: Soldner, Frank — Albert Einstein College of Medicine
- Study coordinator: Soldner, Frank
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.