Investigating how ABCA7 affects lipid levels in brain cells related to Alzheimer's disease
Official title: Specificity of ABCA7-mediated lipid efflux and its effects on intracellular lipid metabolism in neural cells
Funded at Temple Univ of the Commonwealth · NIH-10750993 · Data updated 2026-11-12
This study is looking at how a protein called ABCA7 affects fat processing in brain cells, which could help us understand more about Alzheimer's disease and potentially lead to new treatments for it.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Temple Univ of the Commonwealth NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | January 1, 2023 |
| Project end | December 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $198,125 |
| NIH project number | 5R21AG080729-02 |
| Project ID | NIH-10750993 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals at risk for Alzheimer's disease, particularly those with genetic predispositions or early symptoms.
✕Less likely to help
Patients with advanced Alzheimer's disease or those without any genetic risk factors for the condition may not benefit from this research.
What this research studies
This research focuses on understanding the role of the ABCA7 protein in lipid metabolism within neural cells, particularly in the context of Alzheimer's disease. By examining how ABCA7 mediates the efflux of lipids, the study aims to uncover its impact on the development of Alzheimer's pathology. The approach includes genetic investigations and analysis of lipid composition in brain cells, which may reveal new insights into the mechanisms behind Alzheimer's disease. Patients may benefit from findings that could lead to novel therapeutic strategies targeting lipid metabolism.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that help prevent or slow the progression of Alzheimer's disease.
How similar studies have gone: Previous research has shown promising results in understanding lipid metabolism's role in Alzheimer's disease, indicating that this approach may yield valuable insights.
Where this research is happening
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Temple Univ of the Commonwealth
Philadelphia, United States Active
Researchers
- Principal investigator: Lyssenko, Nicholas — Temple Univ of the Commonwealth
- Study coordinator: Lyssenko, Nicholas
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.