Investigating how a zinc transporter affects brain development in mice
Official title: The Role of Mouse Zinc Transporter ZIP12 in Brain Development
Funded at Oklahoma State University Stillwater · NIH-10876050 · Data updated 2026-11-12
This study is looking at how a special protein that helps move zinc in the brain affects brain development in young people, with hopes of finding ways to improve thinking skills and prevent issues like Alzheimer's in kids and young adults.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oklahoma State University Stillwater NIH-funded |
| Lab location | 1 site (Stillwater, United States) |
| Project start | April 24, 2024 |
| Project end | March 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $445,552 |
| NIH project number | 1R15HD112892-01A1 |
| Project ID | NIH-10876050 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include children and young adults at risk for neurodevelopmental disorders.
✕Less likely to help
Patients with established neurodevelopmental disorders who are beyond the age range of this study may not receive benefit from this research.
What this research studies
This research focuses on understanding the role of the ZIP12 zinc transporter in brain development, particularly in young individuals. By studying genetically modified mice that lack this transporter, researchers aim to uncover how zinc metabolism influences neuronal development and cognitive function. The study will explore the genetic and environmental factors that contribute to neurodevelopmental disorders, with the goal of identifying potential nutritional interventions to prevent or mitigate cognitive deficits. This research could provide insights into the mechanisms behind conditions like Alzheimer's disease in children and young adults.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating neurodevelopmental disorders in young individuals.
How similar studies have gone: Previous research has shown success in understanding the role of nutrient metabolism in brain development, but the specific role of ZIP12 in mammals is still being explored.
Where this research is happening
-
Oklahoma State University Stillwater
Stillwater, United States Active
Researchers
- Principal investigator: Chowanadisai, Winyoo — Oklahoma State University Stillwater
- Study coordinator: Chowanadisai, Winyoo
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.