Investigating how a virus influences skin cancer development
Merkel cell polyomavirus T-Antigen mediated reprogramming in adult epidermis
This study is looking at how a virus related to a rare skin cancer called Merkel cell carcinoma might change skin cells to help the cancer grow, with the hope that understanding this process could lead to better treatments for patients.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11030228 on NIH RePORTER |
What this research studies
This research focuses on Merkel cell carcinoma (MCC), a rare skin cancer linked to the Merkel cell polyomavirus. The study aims to understand how the virus's T-antigens reprogram skin cells, particularly those involved in the development of Merkel cells, to promote tumor growth. By exploring the mechanisms behind this transformation, the research seeks to uncover the relationship between latent viral infection and the onset of cancer. Patients may benefit from insights that could lead to new treatment strategies for MCC.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults diagnosed with Merkel cell carcinoma or those with a history of Merkel cell polyomavirus infection.
Not a fit: Patients with other types of skin cancer unrelated to Merkel cell polyomavirus may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients with Merkel cell carcinoma.
How similar studies have performed: Previous research has shown promising results in understanding viral contributions to cancer, suggesting that this approach may yield valuable insights.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Weber, Madison — Icahn School of Medicine at Mount Sinai
- Study coordinator: Weber, Madison
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.