Investigating how a virus contributes to certain lymphomas in AIDS patients
Official title: Exposing synthetic lethal vulnerabilities in EBV-positive AIDS-NHL through novel replication dependency factors
Funded at University of Florida · NIH-10919868 · Data updated 2026-11-12
This study is looking at how the Epstein-Barr virus might help cause lymphomas in people with HIV/AIDS, and it aims to find new ways to treat these cancers by discovering important proteins involved in this process.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project start | September 4, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $599,564 |
| NIH project number | 5R01DE032623-02 |
| Project ID | NIH-10919868 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with HIV/AIDS who have developed EBV-positive lymphomas.
✕Less likely to help
Patients without HIV/AIDS or those with lymphomas not associated with EBV may not benefit from this research.
What this research studies
This research focuses on understanding how the Epstein-Barr virus (EBV) contributes to the development of lymphomas in individuals with HIV/AIDS. The study aims to explore the mechanisms by which EBV drives the replication of cancer cells, particularly in B cells, and how these cancer cells manage replication stress. By utilizing advanced techniques like mass spectrometry, researchers hope to identify novel proteins that play a critical role in this process, potentially leading to new therapeutic targets for treatment.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for patients with EBV-positive AIDS-related lymphomas.
How similar studies have gone: While the specific approach of targeting EBV-driven replication stress is novel, previous research has shown promise in understanding virus-associated cancers.
Where this research is happening
-
University of Florida
Gainesville, United States Active
Researchers
- Principal investigator: Bhaduri-Mcintosh, Sumita — University of Florida
- Study coordinator: Bhaduri-Mcintosh, Sumita
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.