Investigating how a virus contributes to certain lymphomas in AIDS patients
Exposing synthetic lethal vulnerabilities in EBV-positive AIDS-NHL through novel replication dependency factors
This study is looking at how the Epstein-Barr virus might help cause lymphomas in people with HIV/AIDS, and it aims to find new ways to treat these cancers by discovering important proteins involved in this process.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-10919868 on NIH RePORTER |
What this research studies
This research focuses on understanding how the Epstein-Barr virus (EBV) contributes to the development of lymphomas in individuals with HIV/AIDS. The study aims to explore the mechanisms by which EBV drives the replication of cancer cells, particularly in B cells, and how these cancer cells manage replication stress. By utilizing advanced techniques like mass spectrometry, researchers hope to identify novel proteins that play a critical role in this process, potentially leading to new therapeutic targets for treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with HIV/AIDS who have developed EBV-positive lymphomas.
Not a fit: Patients without HIV/AIDS or those with lymphomas not associated with EBV may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for patients with EBV-positive AIDS-related lymphomas.
How similar studies have performed: While the specific approach of targeting EBV-driven replication stress is novel, previous research has shown promise in understanding virus-associated cancers.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Bhaduri-Mcintosh, Sumita — University of Florida
- Study coordinator: Bhaduri-Mcintosh, Sumita
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.