Investigating how a virus can switch between latency and active infection
Official title: Studies on Viral Enhancer for Latency-Lytic Switch
Funded at University of California at Davis · NIH-11052059 · Data updated 2026-11-12
This study is looking at a virus that can cause certain cancers in people with HIV, and it aims to understand how the virus works in order to find new ways to treat these cancers, which could help improve care for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project start | January 1, 2025 |
| Project end | December 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $564,698 |
| NIH project number | 1R01CA290700-01A1 |
| Project ID | NIH-11052059 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals living with HIV who are at risk for or currently have KSHV-related malignancies.
✕Less likely to help
Patients who do not have HIV or KSHV-related cancers may not benefit from this research.
What this research studies
This research focuses on understanding the Kaposi’s sarcoma-associated herpesvirus (KSHV), which is linked to several cancers in HIV-positive individuals. The study aims to explore the 3D structure of the virus's genome and how it interacts with cellular factors to regulate gene expression. By identifying new drug targets, the research seeks to improve treatment options for patients suffering from KSHV-related malignancies. Patients may benefit from insights that could lead to more effective therapies for these cancers.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for cancers associated with HIV, improving patient outcomes.
How similar studies have gone: Previous research has shown promise in understanding viral gene regulation and its implications for cancer treatment, indicating potential for success in this area.
Where this research is happening
-
University of California at Davis
Davis, United States Active
Researchers
- Principal investigator: Izumiya, Yoshihiro — University of California at Davis
- Study coordinator: Izumiya, Yoshihiro
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.