Investigating how a virus alters metabolism in cancer cells
Official title: KSHV-mediated metabolic reprogramming for LANA expression and viral persistency
Funded at Cleveland Clinic Lerner Com-Cwru · NIH-11116980 · Data updated 2026-11-12
This study is looking at how a virus linked to Kaposi's sarcoma affects the way cancer cells use energy in a more realistic lab setting, which could help us find better ways to treat this type of cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | June 14, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $675,416 |
| NIH project number | 5R01AI181758-02 |
| Project ID | NIH-11116980 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Kaposi's sarcoma or pleural effusion lymphoma, particularly those with a known association with KSHV.
✕Less likely to help
Patients with cancers unrelated to KSHV or those who do not have a diagnosis of Kaposi's sarcoma or pleural effusion lymphoma may not benefit from this research.
What this research studies
This research focuses on how Kaposi’s sarcoma-associated herpesvirus (KSHV) changes the metabolism of cancer cells, particularly in a three-dimensional (3D) environment that better mimics real human conditions. By studying the virus's impact on specific metabolic pathways, the research aims to understand how these changes contribute to the persistence of the virus and the development of cancers like Kaposi's sarcoma. The approach involves advanced cell culture techniques that allow for a more accurate representation of how cancer cells behave in the body, which could lead to new insights into cancer treatment.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for targeting cancer metabolism, potentially improving treatment options for patients with KSHV-related cancers.
How similar studies have gone: Previous research has shown success in understanding cancer metabolism through similar approaches, indicating a promising avenue for further exploration.
Where this research is happening
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Cleveland Clinic Lerner Com-Cwru
Cleveland, United States Active
Researchers
- Principal investigator: Jung, Jae U — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Jung, Jae U
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.