Investigating how a viral protein interacts with a host protein to affect Alzheimer's disease.
Official title: The One Ring to Rule Them All: How ICP0’s Ring Finger in Alliance with the Host Protein CIN85 Regulates Protein Trafficking and Communication
Funded at University of Kansas Medical Center · NIH-10995894 · Data updated 2026-11-12
This study is looking at how a protein from the herpes virus interacts with a protein in our cells to see how it affects our immune system and could play a role in diseases like Alzheimer's, helping us understand more about these conditions.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kansas Medical Center NIH-funded |
| Lab location | 1 site (Kansas City, United States) |
| Project start | January 3, 2025 |
| Project end | January 2, 2028 |
| Funding year | 2024 |
| Award (this year) | $37,460 |
| NIH project number | 1F31AI186315-01 |
| Project ID | NIH-10995894 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with Alzheimer's disease or those experiencing cognitive decline associated with viral infections.
✕Less likely to help
Patients with non-neurodegenerative conditions or those not affected by HSV-1 may not receive any benefit from this research.
What this research studies
This research explores the role of the herpes simplex virus-1 (HSV-1) protein ICP0 and its interaction with the host protein CIN85 in regulating protein trafficking and communication within cells. By understanding how ICP0 influences the immune response and contributes to neurodegenerative diseases like Alzheimer's, the research aims to uncover potential mechanisms that exacerbate these conditions. The study employs advanced cellular techniques to analyze the behavior of these proteins in both infected and uninfected cells, providing insights into their functions and interactions.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing Alzheimer's disease and other neurodegenerative conditions linked to viral infections.
How similar studies have gone: Previous research has shown that understanding viral interactions with host proteins can lead to significant advancements in treating neurodegenerative diseases, indicating a promising avenue for this investigation.
Where this research is happening
-
University of Kansas Medical Center
Kansas City, United States Active
Researchers
- Principal investigator: Lasnier, Sarah — University of Kansas Medical Center
- Study coordinator: Lasnier, Sarah
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.