Investigating how a viral protein contributes to liver cancer development.
How does a metallocofactor in the Hepatitis B viral protein X orchestrate pathogenesis and liver cancer?
This study is looking at a specific protein from the Hepatitis B virus that might play a role in causing liver cancer, and it's for anyone interested in understanding how this virus can affect liver health and lead to cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brandeis University NIH-funded |
| Lab location | 1 site (Waltham, United States) |
| Project ID | NIH-10642956 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of the Hepatitis B virus (HBV) protein X in causing liver cancer. The team is exploring how this protein interacts with other cellular components and how it may alter cellular processes that lead to cancer. By studying the structure and function of this protein, the researchers aim to uncover the molecular mechanisms behind HBV-related liver diseases. This could involve examining how the protein's interactions and modifications affect its behavior and contribute to tumor development.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with chronic Hepatitis B infection who are at risk for liver cancer.
Not a fit: Patients who do not have Hepatitis B infection or those with other unrelated cancers may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating liver cancer associated with Hepatitis B infection.
How similar studies have performed: Previous research has shown promising results in understanding viral proteins and their roles in cancer, suggesting that this approach could yield valuable insights.
Where this research is happening
Waltham, United States
- Brandeis University — Waltham, United States (Active)
Researchers
- Principal investigator: Pandelia, Maria-Eirini — Brandeis University
- Study coordinator: Pandelia, Maria-Eirini
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.