Investigating how a viral protein affects kidney disease in HIV patients
The role of Vpr-mediated cell cycle dysregulation in HIV-associated kidney disease
This study is looking at how a viral protein called Vpr affects kidney health in people with HIV, even when their viral levels are low, to find new ways to help prevent kidney disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10887493 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of a specific viral protein, Vpr, in causing kidney disease among individuals living with HIV. It aims to explore how Vpr leads to cell cycle dysregulation and contributes to chronic kidney disease, even in patients with low viral loads. The study will utilize both laboratory techniques and animal models to examine the effects of Vpr on kidney cells and identify potential therapeutic interventions. By analyzing these mechanisms, the research seeks to provide insights into the progression of kidney disease in HIV-infected patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who are experiencing or at risk for chronic kidney disease.
Not a fit: Patients without HIV or those who do not have any kidney-related complications may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for chronic kidney disease in HIV patients, potentially reducing the incidence of end-stage kidney disease.
How similar studies have performed: Previous studies have shown that understanding viral mechanisms can lead to significant advancements in treating HIV-related complications, suggesting potential success for this approach.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Lee, Kyung — Icahn School of Medicine at Mount Sinai
- Study coordinator: Lee, Kyung
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.