Investigating how a viral protein affects cancer growth in certain lymphomas
Role of Epstein-Barr virus LMP2A protein in maintaining oncogenic IgM signaling in EBV+ B cell lymphomas
This study is looking at how a protein from the Epstein-Barr virus might help certain types of B cell lymphomas grow in people with HIV, and it hopes to find new ways to treat these cancers by figuring out how this protein works with the B cell receptor.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project ID | NIH-10876339 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of the Epstein-Barr virus (EBV) LMP2A protein in promoting the growth of specific types of B cell lymphomas, particularly in patients with HIV. The study aims to explore how LMP2A interacts with the B cell receptor to maintain a growth-promoting form of the receptor, which could lead to new treatment strategies. By examining the differences between EBV-infected cells that express LMP2A and those that do not, researchers hope to identify potential vulnerabilities in the cancer cells that could be targeted with new therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with EBV-positive B cell lymphomas, especially those co-infected with HIV.
Not a fit: Patients with lymphomas that are not associated with EBV or those without HIV may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients with EBV-related lymphomas, particularly those who are HIV-positive.
How similar studies have performed: Previous research has shown promising results in targeting viral oncogenes in cancer treatment, suggesting that this approach could be effective.
Where this research is happening
Madison, United States
- University of Wisconsin-Madison — Madison, United States (Active)
Researchers
- Principal investigator: Johannsen, Eric C — University of Wisconsin-Madison
- Study coordinator: Johannsen, Eric C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.