Investigating how a sugar modification affects breast cancer progression
Role of O-GlcNAc-ylation on tumor progression
This study is looking at how a certain sugar change in breast cancer cells affects their growth and ability to resist treatment, with the hope of finding new ways to help patients fight the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project ID | NIH-11060047 on NIH RePORTER |
What this research studies
This research explores the role of a specific sugar modification, O-GlcNAc-ylation, on the behavior of breast cancer cells. It examines how changes in glucose levels can influence cancer cell signaling and growth, particularly through a pathway known as Hedgehog/GLI. By analyzing the effects of inhibiting the pathway that produces this sugar modification, the research aims to understand how it contributes to cancer cell invasiveness and resistance to treatment. Patients may benefit from insights that could lead to new therapeutic strategies targeting these mechanisms.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with breast cancer, particularly those exhibiting aggressive or treatment-resistant forms of the disease.
Not a fit: Patients with non-cancerous conditions or those with early-stage breast cancer may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that reduce breast cancer invasiveness and improve patient outcomes.
How similar studies have performed: Previous research has shown promising results in targeting similar pathways in cancer treatment, suggesting potential for success in this approach.
Where this research is happening
Birmingham, United States
- University of Alabama at Birmingham — Birmingham, United States (Active)
Researchers
- Principal investigator: Shevde, Lalita a. — University of Alabama at Birmingham
- Study coordinator: Shevde, Lalita a.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.