Investigating how a specific virus affects immune response in hamsters
Official title: Development of antibodies to specific cell surface markers to assess macrophage polarization during Adenovirus 14 and 14p1 infection in the Syrian hamster
Funded at Idaho Veterans Research / Education Fdn · NIH-10849825 · Data updated 2026-11-12
This study is looking at how a strong strain of adenovirus impacts the immune system, especially how certain immune cells called macrophages respond, using Syrian hamsters to help us learn more about treating severe respiratory infections.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Idaho Veterans Research / Education Fdn NIH-funded |
| Lab location | 1 site (Boise, United States) |
| Project start | June 1, 2023 |
| Project end | May 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $62,300 |
| NIH project number | 5R03AI178251-02 |
| Project ID | NIH-10849825 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced severe respiratory infections or are at high risk for developing acute respiratory distress syndrome.
✕Less likely to help
Patients with mild or self-limiting adenovirus infections may not receive any benefit from this research.
What this research studies
This research focuses on understanding how a virulent strain of adenovirus affects the immune response, particularly the polarization of macrophages, which are crucial immune cells. By using Syrian hamsters as a model, the study aims to assess how the virus alters the inflammatory response during infection. The researchers will develop antibodies to specific cell surface markers to evaluate the immune response and identify potential therapeutic targets. This approach could lead to better understanding and treatment options for severe respiratory infections.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for severe respiratory infections, potentially reducing mortality rates associated with conditions like acute respiratory distress syndrome.
How similar studies have gone: While the specific approach of this research is novel, similar studies have shown that understanding immune responses to viral infections can lead to significant advancements in treatment.
Where this research is happening
-
Idaho Veterans Research / Education Fdn
Boise, United States Active
Researchers
- Principal investigator: Radke, Jay R — Idaho Veterans Research / Education Fdn
- Study coordinator: Radke, Jay R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.