Investigating how a specific TDP43 protein variant contributes to neurodegeneration in FTD and ALS
Atypical TDP43 isoforrms driving neurodegeneration in FTD/ALS
['FUNDING_R01'] · UNIVERSITY OF MICHIGAN AT ANN ARBOR · NIH-10747395
This study is looking at a special version of a protein called TDP43 to see how it affects brain cells in people with frontotemporal dementia and ALS, with the goal of finding new ways to help improve their condition.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MICHIGAN AT ANN ARBOR (nih funded) |
| Locations | 1 site (ANN ARBOR, UNITED STATES) |
| Trial ID | NIH-10747395 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of a unique variant of the TDP43 protein in the development of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). It aims to explore how this variant, which is mislocalized within neurons, contributes to neuronal hyperexcitability and neurodegeneration. By examining the relationship between this TDP43 variant and neuronal activity, the researchers hope to uncover new therapeutic strategies that could restore normal TDP43 function and improve patient outcomes. The study employs both in vitro and in vivo models to investigate these mechanisms.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with frontotemporal dementia or amyotrophic lateral sclerosis.
Not a fit: Patients with other forms of dementia or neurodegenerative diseases unrelated to TDP43 pathology may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that slow down or prevent the progression of FTD and ALS.
How similar studies have performed: Previous research has shown promising results in understanding TDP43 pathology, indicating potential for breakthroughs in treatment approaches.
Where this research is happening
ANN ARBOR, UNITED STATES
- UNIVERSITY OF MICHIGAN AT ANN ARBOR — ANN ARBOR, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BARMADA, SAMI — UNIVERSITY OF MICHIGAN AT ANN ARBOR
- Study coordinator: BARMADA, SAMI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Amyotrophic Lateral Sclerosis Motor Neuron Disease, Gehrig's Disease, Lou Gehrig Disease