Investigating how a specific sugar molecule affects Alzheimer's disease and its risk factors
Microglial heparan sulfate in the modulation of APOE function and neurodegeneration
This study is looking at how a sugar molecule on our cells and a specific gene linked to Alzheimer's disease work together, which could help us find new ways to treat or prevent Alzheimer's, especially for those who are most affected by it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sanford Burnham Prebys Medical Discovery Institute NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10992661 on NIH RePORTER |
What this research studies
This research explores the role of heparan sulfate, a sugar molecule found on cell surfaces, in the development of Alzheimer's disease, particularly the late-onset type that affects most patients. It examines how variations in the APOE gene, which is a significant risk factor for Alzheimer's, interact with microglial cells and heparan sulfate to influence neurodegeneration. By understanding these interactions, the research aims to uncover the molecular mechanisms that contribute to Alzheimer's disease and identify potential therapeutic targets. Patients may benefit from insights that could lead to new treatments or preventive strategies for Alzheimer's.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for late-onset Alzheimer's disease, particularly those with specific APOE gene variations.
Not a fit: Patients with early-onset Alzheimer's disease or those without genetic risk factors related to APOE may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for preventing or treating Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in understanding the role of APOE in Alzheimer's, suggesting that this approach could yield valuable insights.
Where this research is happening
La Jolla, United States
- Sanford Burnham Prebys Medical Discovery Institute — La Jolla, United States (Active)
Researchers
- Principal investigator: Yamaguchi, Yu — Sanford Burnham Prebys Medical Discovery Institute
- Study coordinator: Yamaguchi, Yu
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.