Investigating how a specific signaling pathway affects kidney complications in diabetes
Renal diabetic complications mediated by the PAR1 signaling in podocytes
['FUNDING_R01'] · UNIVERSITY OF SOUTH FLORIDA · NIH-11127420
This study is looking at how certain kidney cells called podocytes are affected by diabetes and how a specific medication might help protect them from damage, with the goal of finding better ways to manage kidney problems for people with diabetes.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF SOUTH FLORIDA (nih funded) |
| Locations | 1 site (TAMPA, UNITED STATES) |
| Trial ID | NIH-11127420 on ClinicalTrials.gov |
What this research studies
This research focuses on the role of podocytes, specialized cells in the kidneys, in the development of diabetic kidney disease (DKD). It aims to understand how the activation of certain receptors, known as protease-activated receptors (PARs), influences calcium levels in podocytes, which can lead to kidney damage. By studying the effects of a specific PAR1 antagonist, Vorapaxar, the research seeks to uncover new therapeutic strategies for managing kidney complications in patients with diabetes. The approach includes both laboratory experiments and analysis of clinical data to establish the relationship between PAR signaling and kidney health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with adult-onset diabetes who are at risk for or experiencing diabetic kidney disease.
Not a fit: Patients without diabetes or those with kidney disease from non-diabetic causes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent or reduce kidney damage in patients with diabetes.
How similar studies have performed: Previous studies have shown promising results with similar approaches, particularly the beneficial effects of PAR1 antagonists in type 2 diabetes.
Where this research is happening
TAMPA, UNITED STATES
- UNIVERSITY OF SOUTH FLORIDA — TAMPA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: STARUSCHENKO, ALEXANDER — UNIVERSITY OF SOUTH FLORIDA
- Study coordinator: STARUSCHENKO, ALEXANDER
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: adult onset diabetes, Adult-Onset Diabetes Mellitus