Investigating how a specific signaling pathway affects bone hormone production
Skeletal FGF23 production mediated by GPCR/Gq/PKC signaling
This study is looking at how a hormone called FGF23, which helps manage phosphate and vitamin D in the body, works in people with kidney disease, with the hope of finding better ways to treat bone and mineral problems related to this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10816451 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of fibroblast growth factor-23 (FGF23), a hormone produced by bones that regulates phosphate levels and vitamin D metabolism. The study aims to uncover the mechanisms that control FGF23 production, particularly in the context of kidney disease where FGF23 levels are often elevated. By exploring the signaling pathways involved, specifically the G protein-coupled receptor signaling, the research seeks to identify potential therapeutic targets for managing bone and mineral disorders. Patients may benefit from improved treatment strategies that arise from a better understanding of FGF23 regulation.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients with chronic kidney disease or other conditions associated with abnormal FGF23 levels.
Not a fit: Patients without any bone or mineral metabolism disorders are unlikely to benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for bone and mineral disorders, particularly in patients with chronic kidney disease.
How similar studies have performed: Previous research has shown success in targeting similar signaling pathways for other hormonal regulations, indicating potential for this approach.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Bastepe, Murat — Massachusetts General Hospital
- Study coordinator: Bastepe, Murat
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.