Investigating how a specific serotonin receptor affects cocaine use
5-HT7 receptor modulation of cocaine effects
This study is looking at how a specific brain receptor might affect cocaine addiction, using animal models to see how different substances can change cocaine-seeking behavior, with the hope of finding new ways to help people who are struggling with cocaine use.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Arizona State University-Tempe Campus NIH-funded |
| Lab location | 1 site (Tempe, United States) |
| Project ID | NIH-10669301 on NIH RePORTER |
What this research studies
This research explores the role of the 5-HT7 receptor in cocaine use disorders, focusing on how it influences behaviors related to cocaine addiction. By using animal models, the study will assess the effects of both agonists and antagonists of the 5-HT7 receptor on cocaine self-administration and motivation for cocaine. The research aims to understand the underlying neural processes that contribute to cocaine addiction, which could lead to new treatment options for individuals struggling with cocaine use. The findings may provide insights into how serotonin receptors can be targeted to modify addictive behaviors.
Who could benefit from this research
Good fit: Ideal candidates for this research would be individuals with cocaine use disorders or those at risk of developing such disorders.
Not a fit: Patients who do not use cocaine or have no history of substance use disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new pharmacological therapies for cocaine use disorders, potentially reducing addiction and improving patient outcomes.
How similar studies have performed: While the specific role of the 5-HT7 receptor in cocaine use disorders has not been extensively studied, there is evidence that similar approaches targeting serotonin receptors have shown promise in other substance use disorders.
Where this research is happening
Tempe, United States
- Arizona State University-Tempe Campus — Tempe, United States (Active)
Researchers
- Principal investigator: Olive, M. Foster — Arizona State University-Tempe Campus
- Study coordinator: Olive, M. Foster
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.