Investigating how a specific RNA structure affects energy production in cells
Human COX7B Contains a cAMP-Responsive Riboswitch that Modulates Oxidative Phosphorylation
This study is exploring a special part of our cells called a riboswitch that helps control how our body uses energy, and by learning more about it, researchers hope to find new ways to help people with metabolic disorders.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project ID | NIH-10827218 on NIH RePORTER |
What this research studies
This research focuses on a unique RNA structure called a riboswitch, which can regulate gene expression in response to metabolic changes. The team is using advanced techniques to identify and study these riboswitches in human cells, particularly looking at one that interacts with a protein involved in energy production. By understanding how this riboswitch influences cellular respiration, the research aims to uncover new insights into metabolic regulation and its implications for health. Patients may benefit from findings that could lead to novel treatments for metabolic disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with metabolic disorders or conditions related to energy production in cells.
Not a fit: Patients with unrelated health conditions or those not experiencing metabolic issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing metabolic disorders and improving energy production in cells.
How similar studies have performed: While riboswitches have been extensively studied in bacteria, this research is exploring their role in eukaryotic cells, making it a novel approach.
Where this research is happening
Salt Lake City, United States
- University of Utah — Salt Lake City, United States (Active)
Researchers
- Principal investigator: Skabelund, Rachel Anne — University of Utah
- Study coordinator: Skabelund, Rachel Anne
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.