Investigating how a specific RNA influences non-small cell lung cancer
Official title: Understanding the role of RAMS11 in non small cell lung cancer
Funded at Washington University · NIH-11130224 · Data updated 2026-11-12
This study is looking at a specific type of RNA called RAMS11 to see how it helps non-small cell lung cancer grow and spread, with the hope of finding new ways to treat patients like you more effectively.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | June 1, 2025 |
| Project end | May 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $355,706 |
| NIH project number | 1R01CA293071-01A1 |
| Project ID | NIH-11130224 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with non-small cell lung cancer, particularly those with mutations in the NRF2 signaling pathway.
✕Less likely to help
Patients with other types of lung cancer or those without the specific mutations being studied may not benefit from this research.
What this research studies
This research aims to understand the role of long noncoding RNAs, specifically RAMS11, in promoting non-small cell lung cancer (NSCLC). By focusing on how these RNAs contribute to tumor growth and metastasis, the study seeks to identify new biomarkers and develop targeted therapies for patients. The approach includes computational analysis and RNA sequencing to explore the relationship between RAMS11 and mutations in the NRF2 signaling pathway, which is often altered in NSCLC. Patients may benefit from insights that could lead to more effective treatment options tailored to their specific cancer characteristics.
Why it matters
Potential benefit: If successful, this research could lead to the development of new biomarkers and targeted therapies that improve outcomes for patients with non-small cell lung cancer.
How similar studies have gone: Other research has shown promise in targeting long noncoding RNAs in cancer, suggesting that this approach could yield significant insights and advancements.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Maher, Christopher a — Washington University
- Study coordinator: Maher, Christopher a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.