Investigating how a specific RNA influences heart and blood cell development.
Long non-coding RNA MCRL1 regulates human cardiac and hematopoietic differentiation via interacting with β-Catenin
['FUNDING_R01'] · INDIANA UNIVERSITY INDIANAPOLIS · NIH-11131705
This study is looking at how a special molecule called MCRL1 helps shape heart and blood cells from human stem cells, which could lead to new insights about how our bodies develop these important tissues.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | INDIANA UNIVERSITY INDIANAPOLIS (nih funded) |
| Locations | 1 site (INDIANAPOLIS, UNITED STATES) |
| Trial ID | NIH-11131705 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of a long non-coding RNA called MCRL1 in the development of heart and blood cells from human embryonic stem cells. By examining how MCRL1 interacts with the Wnt/β-Catenin signaling pathway during the critical stage of mesoderm specification, the researchers aim to uncover unique human mechanisms that guide the formation of these essential tissues. The study employs advanced techniques such as ATAC sequencing to analyze chromatin accessibility and gene regulation during differentiation processes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to heart and blood cell development or those interested in advancements in regenerative medicine.
Not a fit: Patients with established heart or blood conditions that are not related to developmental processes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into heart and blood cell development, potentially informing future therapies for cardiovascular diseases and blood disorders.
How similar studies have performed: Previous research has shown success in understanding the roles of long non-coding RNAs in cardiovascular development, indicating that this approach has potential for meaningful discoveries.
Where this research is happening
INDIANAPOLIS, UNITED STATES
- INDIANA UNIVERSITY INDIANAPOLIS — INDIANAPOLIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: YANG, LEI — INDIANA UNIVERSITY INDIANAPOLIS
- Study coordinator: YANG, LEI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.