Investigating how a specific RNA in brain cells affects memory as we age
Long Non-coding RNA Regulation in Astrocytes within the Aging Brain
This study is looking at how a specific molecule in brain support cells called Neat1 affects memory in older adults, with the goal of finding ways to help improve memory as we age.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project ID | NIH-11080315 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of a long non-coding RNA called Neat1 in astrocytes, which are supportive cells in the brain, and how it influences memory resilience in aging individuals. The study aims to uncover the epigenetic mechanisms that control gene expression in these cells, particularly in the hippocampus, an area critical for memory. By manipulating Neat1 levels in astrocytes, the researchers hope to identify potential interventions that could enhance memory function in older adults. This research is particularly important as it addresses a gap in knowledge regarding how astrocytes contribute to memory changes with age.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing memory challenges or age-related cognitive decline.
Not a fit: Patients with acute neurological conditions or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for improving memory function in older adults.
How similar studies have performed: While the specific focus on astrocytic lncRNAs is novel, similar research has shown promising results in understanding epigenetic factors affecting memory.
Where this research is happening
Birmingham, United States
- University of Alabama at Birmingham — Birmingham, United States (Active)
Researchers
- Principal investigator: Lubin, Farah Dominique — University of Alabama at Birmingham
- Study coordinator: Lubin, Farah Dominique
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.