Investigating how a specific RNA affects liver disease caused by alcohol
Official title: Long Noncoding RNA H19 Mediating Alternative Splicing in ALD Pathogenesis
Funded at Indiana University Indianapolis · NIH-10907785 · Data updated 2026-11-12
This study is looking at how a specific molecule called H19 might affect liver damage caused by drinking alcohol, and it's aimed at finding new ways to help people with alcohol-related liver disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project start | August 15, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $400,881 |
| NIH project number | 5R01AA030993-02 |
| Project ID | NIH-10907785 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with a history of excessive alcohol consumption and related liver issues.
✕Less likely to help
Patients who do not consume alcohol or have liver disease unrelated to alcohol may not benefit from this research.
What this research studies
This research focuses on understanding the role of a long noncoding RNA called H19 in the development of alcohol-associated liver disease (ALD). Researchers will explore how H19 expression is influenced by alcohol consumption and its potential to mediate liver injury. Using specialized mouse models, they will investigate the molecular mechanisms behind H19's function, including its interactions with proteins that may contribute to liver damage. The goal is to uncover new therapeutic targets for treating ALD.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for patients suffering from alcohol-associated liver disease.
How similar studies have gone: Previous research has shown promising results in understanding the role of noncoding RNAs in various diseases, suggesting potential for success in this area as well.
Where this research is happening
-
Indiana University Indianapolis
Indianapolis, United States Active
Researchers
- Principal investigator: Yang, Zhihong — Indiana University Indianapolis
- Study coordinator: Yang, Zhihong
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.