Investigating how a specific RNA affects inflammation and artery disease in diabetes
LncRNA MERRICAL, macrophage chemotaxis, and diabetes-associated atherosclerosis
This study is looking at how a specific RNA called MERRICAL affects heart health in people with diabetes by influencing immune cells that can lead to artery disease, with the hope of finding new ways to help slow down or even reverse this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11128441 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of a long non-coding RNA called MERRICAL in the progression of atherosclerosis, particularly in individuals with diabetes. It aims to explore how this RNA influences the behavior of macrophages, which are immune cells that can contribute to artery disease. By using advanced RNA sequencing techniques, the study will identify how MERRICAL levels change in response to dietary factors and disease progression. The ultimate goal is to find new ways to slow down or reverse artery disease in diabetic patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with diabetes who are at risk for atherosclerosis or have been diagnosed with cardiovascular disease.
Not a fit: Patients without diabetes or those who do not have atherosclerosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that reduce the risk of heart disease in patients with diabetes.
How similar studies have performed: Previous research has shown promise in targeting macrophage behavior to treat atherosclerosis, suggesting that this approach could be effective.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Feinberg, Mark W — Brigham and Women's Hospital
- Study coordinator: Feinberg, Mark W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.