Investigating how a specific RNA affects glioblastoma growth and treatment resistance
lncRNA regulation of glioblastoma progression and therapeutic resistance
This study is looking at how a specific molecule called Lucat1 affects stubborn brain tumor cells in glioblastoma, with the hope of finding new ways to treat this tough condition and help patients get better care.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-10994173 on NIH RePORTER |
What this research studies
This research focuses on glioblastoma, a highly aggressive brain tumor known for its resistance to standard treatments. The study aims to understand the role of long non-coding RNAs, particularly Lucat1, in the maintenance and progression of glioma stem-like cells, which are crucial for tumor recurrence. By exploring how Lucat1 is regulated by hypoxic conditions within the tumor environment, the researchers hope to uncover new therapeutic strategies to target these resistant cancer cells. Patients may benefit from insights that could lead to more effective treatments for glioblastoma.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with glioblastoma, particularly those with the IDH wild-type subtype.
Not a fit: Patients with other types of brain tumors or those who do not have glioblastoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that specifically target resistant cancer cells in glioblastoma, potentially improving patient outcomes.
How similar studies have performed: Previous research has shown promising results in targeting cancer stem cells, but the specific approach of targeting Lucat1 in glioblastoma is relatively novel.
Where this research is happening
Cleveland, United States
- Cleveland Clinic Lerner Com-Cwru — Cleveland, United States (Active)
Researchers
- Principal investigator: Yu, Jennifer S — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Yu, Jennifer S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.