Investigating how a specific RNA affects gene regulation in breast cancer
Characterization of nuclear-retained RNA-mediated gene regulatory mechanisms
This study is looking at a special molecule called MALAT1 that affects how breast cancer grows and spreads, especially when there's not enough oxygen, to help us understand how cancer cells change their genes to survive in tough conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Illinois at Urbana-Champaign NIH-funded |
| Lab location | 1 site (Champaign, United States) |
| Project ID | NIH-10655466 on NIH RePORTER |
What this research studies
This research focuses on a long non-coding RNA called MALAT1, which plays a crucial role in breast cancer progression and metastasis, particularly under low oxygen conditions (hypoxia). The study aims to understand how MALAT1 influences the alternative splicing of pre-mRNA, which is essential for the proper expression of genes involved in the body's response to hypoxia. By examining the interactions between MALAT1 and splicing factors, the research seeks to uncover the molecular mechanisms that regulate gene expression in cancer cells. This could provide insights into how tumors adapt to their environment and progress.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with breast cancer, particularly those experiencing hypoxic conditions within their tumors.
Not a fit: Patients with non-cancerous conditions or those not diagnosed with breast cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies targeting MALAT1 to inhibit breast cancer progression.
How similar studies have performed: Previous research has shown that targeting non-coding RNAs like MALAT1 can influence cancer progression, indicating potential success for this approach.
Where this research is happening
Champaign, United States
- University of Illinois at Urbana-Champaign — Champaign, United States (Active)
Researchers
- Principal investigator: Kannanganattu, Prasanth Kumar Vijayan — University of Illinois at Urbana-Champaign
- Study coordinator: Kannanganattu, Prasanth Kumar Vijayan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.