Investigating how a specific RNA affects gene organization in acute myeloid leukemia
Role of lncRNA mediated R-loops in CTCF boundary function and AML genome organization
This study is looking at a special molecule called HOTTIP to see how it affects the development of acute myeloid leukemia (AML), with the hope of finding new ways to treat the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Pennsylvania State Univ Hershey Med Ctr NIH-funded |
| Lab location | 1 site (Hershey, United States) |
| Project ID | NIH-10986092 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of a long non-coding RNA (lncRNA) called HOTTIP in the development of acute myeloid leukemia (AML). The study aims to explore how HOTTIP interacts with specific genomic regions to influence gene expression and contribute to the disease's progression. By utilizing advanced techniques such as RNA sequencing and chromatin immunoprecipitation, researchers will analyze the genetic changes associated with AML and how they affect blood cell development. This research could provide insights into the underlying mechanisms of AML and identify potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with acute myeloid leukemia or those with genetic predispositions to the disease.
Not a fit: Patients with other types of leukemia or hematological disorders unrelated to acute myeloid leukemia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating acute myeloid leukemia by targeting the molecular mechanisms involved in its progression.
How similar studies have performed: Previous research has shown promising results in understanding the role of non-coding RNAs in cancer, suggesting that this approach may yield valuable insights.
Where this research is happening
Hershey, United States
- Pennsylvania State Univ Hershey Med Ctr — Hershey, United States (Active)
Researchers
- Principal investigator: Huang, Suming — Pennsylvania State Univ Hershey Med Ctr
- Study coordinator: Huang, Suming
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.