Investigating how a specific RNA affects colorectal cancer spread and resistance to cell death.
Role of lncRNA UCA1 in anoikis resistantce and colorectal cancer metastasis
This study is looking at how a specific molecule called UCA1 helps colorectal cancer cells survive and spread after they detach from the main tumor, which could lead to new ways to treat or prevent this type of cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Rio Grande Valley NIH-funded |
| Lab location | 1 site (Edinburg, United States) |
| Project ID | NIH-10887504 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of a long noncoding RNA (lncRNA) called UCA1 in the spread of colorectal cancer (CRC) and its ability to resist a type of cell death known as anoikis. By studying CRC cell lines, the researchers aim to uncover how UCA1 contributes to the cancer's ability to survive after detaching from the primary tumor, which is a critical step in metastasis. The study will explore the molecular mechanisms involved, potentially leading to new insights into CRC treatment and prevention strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults diagnosed with colorectal cancer, particularly those with metastatic disease.
Not a fit: Patients with early-stage colorectal cancer or those without a diagnosis of colorectal cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic targets that improve survival rates for colorectal cancer patients.
How similar studies have performed: Previous research has shown that targeting specific RNA molecules can influence cancer progression, suggesting that this approach may yield valuable insights.
Where this research is happening
Edinburg, United States
- University of Texas Rio Grande Valley — Edinburg, United States (Active)
Researchers
- Principal investigator: Tripathi, Manish K — University of Texas Rio Grande Valley
- Study coordinator: Tripathi, Manish K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.