Investigating how a specific receptor regulates calcium and phosphate levels in the body.
Structure and function of PTH class B GPCR
['FUNDING_R01'] · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · NIH-11073026
This study is looking for new ways to help people with bone and mineral problems, like osteoporosis, by finding small molecules that can change how a specific receptor in the body works, which could lead to better treatments for these conditions.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PITTSBURGH AT PITTSBURGH (nih funded) |
| Locations | 1 site (PITTSBURGH, UNITED STATES) |
| Trial ID | NIH-11073026 on ClinicalTrials.gov |
What this research studies
This research focuses on the parathyroid hormone type 1 receptor (PTHR), which plays a crucial role in managing calcium and phosphate levels in the blood and bone health. The project aims to identify small molecules that can modulate this receptor's activity, potentially leading to new treatments for conditions like osteoporosis and hypercalcemia. Using advanced computational methods and medicinal chemistry, the researchers will explore how these molecules can influence PTHR signaling. Patients may benefit from new therapies developed through this research that target bone and mineral disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from bone diseases such as osteoporosis or conditions related to abnormal calcium levels.
Not a fit: Patients with bone disorders not related to PTHR signaling or those without significant calcium or phosphate imbalances may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments for bone diseases and disorders related to calcium and phosphate imbalance.
How similar studies have performed: Previous research has successfully identified modulators for similar receptors, indicating a promising avenue for this type of investigation.
Where this research is happening
PITTSBURGH, UNITED STATES
- UNIVERSITY OF PITTSBURGH AT PITTSBURGH — PITTSBURGH, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: VILARDAGA, JEAN-PIERRE — UNIVERSITY OF PITTSBURGH AT PITTSBURGH
- Study coordinator: VILARDAGA, JEAN-PIERRE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.