Investigating how a specific receptor protects the brain after a stroke
Official title: Mechanistic inquiry of GPR68-mediated neuroprotection against post-stroke deficits and VCID
Funded at Tulane University of Louisiana · NIH-11247423 · Data updated 2026-11-12
This study is looking at how a special receptor called GPR68 can help keep brain cells safe during strokes, especially ischemic strokes, and aims to find new ways to prevent long-term problems after a stroke.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Tulane University of Louisiana NIH-funded |
| Lab location | 1 site (New Orleans, United States) |
| Project start | September 25, 2023 |
| Project end | August 31, 2029 |
| Funding year | 2023 |
| Award (this year) | $518,410 |
| NIH project number | 7R01NS135594-02 |
| Project ID | NIH-11247423 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced an ischemic stroke and are at risk for post-stroke cognitive impairments.
✕Less likely to help
Patients who have not experienced a stroke or have other unrelated neurological conditions may not benefit from this research.
What this research studies
This research focuses on understanding how the GPR68 receptor can help protect brain cells from damage caused by strokes, particularly ischemic strokes. By studying both laboratory models and living organisms, the researchers aim to uncover the mechanisms through which GPR68 activates protective responses in neurons during and after a stroke. The goal is to identify new treatments that could prevent long-term cognitive impairments and disabilities that often follow a stroke.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly reduce the risk of cognitive decline and disabilities after a stroke.
How similar studies have gone: Previous research has shown promise in targeting similar neuroprotective mechanisms, suggesting that this approach could be effective.
Where this research is happening
-
Tulane University of Louisiana
New Orleans, United States Active
Researchers
- Principal investigator: Zha, Xiangming — Tulane University of Louisiana
- Study coordinator: Zha, Xiangming
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.