Investigating how a specific receptor protects the brain after a stroke
Mechanistic inquiry of GPR68-mediated neuroprotection against post-stroke deficits and VCID
['FUNDING_R01'] · TULANE UNIVERSITY OF LOUISIANA · NIH-11247423
This study is looking at how a special receptor called GPR68 can help keep brain cells safe during strokes, especially ischemic strokes, and aims to find new ways to prevent long-term problems after a stroke.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | TULANE UNIVERSITY OF LOUISIANA (nih funded) |
| Locations | 1 site (NEW ORLEANS, UNITED STATES) |
| Trial ID | NIH-11247423 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how the GPR68 receptor can help protect brain cells from damage caused by strokes, particularly ischemic strokes. By studying both laboratory models and living organisms, the researchers aim to uncover the mechanisms through which GPR68 activates protective responses in neurons during and after a stroke. The goal is to identify new treatments that could prevent long-term cognitive impairments and disabilities that often follow a stroke.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced an ischemic stroke and are at risk for post-stroke cognitive impairments.
Not a fit: Patients who have not experienced a stroke or have other unrelated neurological conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly reduce the risk of cognitive decline and disabilities after a stroke.
How similar studies have performed: Previous research has shown promise in targeting similar neuroprotective mechanisms, suggesting that this approach could be effective.
Where this research is happening
NEW ORLEANS, UNITED STATES
- TULANE UNIVERSITY OF LOUISIANA — NEW ORLEANS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ZHA, XIANGMING — TULANE UNIVERSITY OF LOUISIANA
- Study coordinator: ZHA, XIANGMING
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.