Investigating how a specific receptor interaction affects pain after spinal cord injury
Exploring the EphB2-NMDA receptor interaction in spinal cord injury-induced neuropathic pain
This study is looking at how two specific receptors in the spinal cord work together and how this affects pain after a spinal cord injury, with the hope of finding new ways to help manage that pain without using opioids.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Thomas Jefferson University NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10882574 on NIH RePORTER |
What this research studies
This research focuses on understanding the interaction between the EphB2 receptor and NMDA receptors in the spinal cord, particularly how this interaction contributes to neuropathic pain following spinal cord injuries. By studying this relationship, researchers aim to identify new targets for pain management that do not rely on opioids, which can have severe side effects. The approach involves examining the molecular mechanisms that regulate this receptor interaction and its impact on pain signaling pathways. Patients with spinal cord injuries may benefit from insights gained through this research, potentially leading to new treatment options.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced spinal cord injuries and suffer from chronic neuropathic pain.
Not a fit: Patients with neuropathic pain not related to spinal cord injuries may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments for neuropathic pain that are more effective and safer than current opioid-based therapies.
How similar studies have performed: Previous research has shown promise in targeting receptor interactions for pain management, suggesting that this approach could yield significant advancements.
Where this research is happening
Philadelphia, United States
- Thomas Jefferson University — Philadelphia, United States (Active)
Researchers
- Principal investigator: Lepore, Angelo C — Thomas Jefferson University
- Study coordinator: Lepore, Angelo C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.