Investigating how a specific receptor can protect nerve cells in glaucoma
The Mechanism of Sigma 1 Receptor Mediated Neuroprotection in Glaucoma
['FUNDING_R01'] · AUGUSTA UNIVERSITY · NIH-11099868
This study is looking at how a special protein in the eye might help protect nerve cells from damage in people with glaucoma, with the hope of finding new treatments to keep your vision healthy.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | AUGUSTA UNIVERSITY (nih funded) |
| Locations | 1 site (AUGUSTA, UNITED STATES) |
| Trial ID | NIH-11099868 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how the sigma-1 receptor (S1R) can help protect retinal ganglion cells (RGCs) from damage in glaucoma, a disease that can lead to blindness. The study aims to explore the role of S1R in regulating the secretions of astrocytes, which are supportive cells in the optic nerve. By using a rat model, researchers will examine how activating S1R can reduce axon loss and promote the health of RGCs. This could lead to new neuroprotective treatments for patients suffering from glaucoma.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults diagnosed with glaucoma who are at risk of vision loss.
Not a fit: Patients with glaucoma who are not responsive to neuroprotective treatments or those with advanced stages of the disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that prevent vision loss in glaucoma patients.
How similar studies have performed: Previous studies have shown that targeting the sigma-1 receptor can reduce axon loss in glaucoma models, indicating potential success for this approach.
Where this research is happening
AUGUSTA, UNITED STATES
- AUGUSTA UNIVERSITY — AUGUSTA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BOLLINGER, KATHRYN — AUGUSTA UNIVERSITY
- Study coordinator: BOLLINGER, KATHRYN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.